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Our laboratory demonstrated that SERT and αvβ3 receptors colocalize in midbrain presynaptic terminals (Mazalouskas et al., 2015), suggesting that SERT is localized to multiprotein complexes coordinated by integrin αvβthree in midbrain synapses. Earlier research recommend that in platelets, the association of SERT with activated αIIbβ3 integrins, and its localization to adhesion complexes, are correlated with amplified uptake exercise (Carneiro et al.

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Engagement of integrins because of the extracellular matrix initiates signaling cascades that drive a number of mobile capabilities, which includes neuronal migration and axonal pathfinding in the Mind. Multiple strains of proof link the ITGB3

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